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C. difficile Infection Programme Summit has generated a comprehensive package of data supporting the potential of the novel class antibiotic ridinilazole as a new front-line treatment of infections caused by the bacteria Clostridium difficile. The Phase 2 proof of concept trial called CoDIFy showed ridinilazole outperformed the antibiotic vancomycin, which is the current standard of care. Ridinilazole demonstrated a large numerical reduction in rates of recurrent disease compared to vancomycin with this difference driven by ridinilazole outperforming vancomycin in the preservation of the gut microbiome. Recurrence of CDI, and the failure to subsequently achieve a sustained clinical response after treatment, is a major issue in the management of the disease, as collateral damage to the gut microbiome by antibiotics such as vancomycin leaves patients vulnerable to disease recurrence. Phase 3 preparations are ongoing as the Company continues to explore options to support the future development of ridinilazole with a view to maximising the potential commercial value of this antibiotic. Summits preference remains finding a third party collaborator although the Company continues to actively explore other potential options, including funding from government and non-profit organisations. In parallel, Summit is undertaking an exploratory Phase 2 trial called CoDIFy 2 to evaluate ridinilazole against the antibiotic fidaxomicin. This trial is intended to further understand the impact of ridinilazole on a number of Recommended Site disease parameters, including its impact on patients gut microbiomes to help inform the design of the Phase 3 clinical programme for ridinilazole.
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Read below . Memphis big man Chad Rykhoek , a graduate transfer who made his NCAA debut earlier this season after an injury-plagued stint at Baylor , was taken off the court on a stretcher with what appeared to be a serious left ankle or leg injury in the first half Saturday against Oklahoma . Rykhoek injured his left leg with 5:14 remaining in the first half after a collision with Oklahoma forward Matt Freeman under the basket after a missed shot. Memphis coach Tubby Smith said after the game that Rykhoek suffered a dislocation and that http://pokentedidly61b56.journalnewsnet.com/-report-of-extracurricular-activities-such-as-field-trips-homeschool-group-or-church-activities-sports-music-drama-etc his recovery timetable is uncertain. The game was delayed for about five minutes after the injury. His leg was immobilized before he was moved, though Rykhoek didn’t appear to be in too much pain. His parents were summoned to the court and members of both teams surrounded him while the Sooners crowd gave him a standing ovation. Rykhoek transferred to Memphis earlier this year after a string of injuries forced him to leave Baylor, where he never played a minute of basketball. The Fort Worth, Texas, native was rated as a top-150 recruit by Rivals when he enrolled at Baylor in 2012. The 6-foot-11 Rykhoek started all 11 of Memphis’ games this season and was averaging 6.4 points and 2.8 rebounds per game entering Saturday.
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